Eddie and Venom are on the run. Hunted by both of their worlds and with the net closing in, the duo are forced into a devastating decision that will bring the curtains down on Venom and Eddie's last dance.

The Guardians struggle to keep together as a team while dealing with their personal family issues, notably Star-Lord's encounter with his father, the ambitious celestial being Ego.

Jean Grey begins to develop incredible powers that corrupt and turn her into a Dark Phoenix, causing the X-Men to have to decide if her life is worth more than all of humanity.

Black Manta seeks revenge on Aquaman for his father's death. Wielding the Black Trident's power, he becomes a formidable foe. To defend Atlantis, Aquaman forges an alliance with his imprisoned brother. They must protect the kingdom.

Mal struggles with her new celebrity life as the girlfriend of King Ben, putting a spell on her hair making it blonde, and maintaining a princess-like personality that she is uncomfortable with. She admits her issues to her friends Evie, Carlos, and Jay, but they are content with their new lives in Auradon and do not wish to return to the Isle of the Lost. Evie scolds Mal for relying on her mother's spell book to solve her issues. Carlos, wishing to ask Jane to the upcoming Cotillion dance, turns to Mal for help to be honest with her. Mal gives him a sweet that will make him speak the truth, but his dog Dude eats it, magically speaking the truth in English and very frankly as a result.